期刊
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
卷 69, 期 5, 页码 299-306出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.etp.2017.02.001
关键词
Cisplatin; Nigella sativa oil; Carbohydrate metabolism; Antioxidant system; Gastrointestinal toxicity
资金
- University Grants Commission (UGC), New Delhi
Cisplatin (CP) is an effective chemotherapeutic agent that induces gastrointestinal toxicity. Nigella sativa oil (NSO) has been shown to be beneficial in a wide range of gastrointestinal disorders. The present study investigates the possible protective effect of NSO on CP-induced gastrointestinal toxicity. NSO administration (2 ml/kg bwt, orally), prior to and following, a single dose CP treatment (6 mg/kg bwt. ip), significantly attenuated the CP-induced decrease in brush border membrane (BBM) enzyme activities in intestinal homogenates and BBM vesicles (BBMV). NSO administration also mitigated CP induced alterations in the activities of carbohydrate metabolism enzymes and in the enzymatic and non enzymatic antioxidant parameters in the intestine. The results suggest that NSO by empowering the endogenous antioxidant system improves intestinal redox and metabolic status and restores BBM integrity in CP treated rats. Histopathological studies supported the biochemical findings. Thus, NSO may help prevent the accompanying gastrointestinal dysfunction in CP chemotherapy. (C) 2017 Elsevier GmbH. All rights reserved.
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