期刊
DISEASE MODELS & MECHANISMS
卷 14, 期 5, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dmm.049051
关键词
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资金
- V Foundation for Cancer Research [V2020-013]
- National Institutes of Health (NIH) [P30 058404]
- American Cancer Society (ACS) Institutional Research Grant [IRG1913959]
- VanderbiltIngram Cancer Center (VICC) GI SPORE grant [P50CA236733]
- United StatesIsrael Binational Science Foundation grant [2019136]
- NIH Gastroenterology Training Grant [T32DK007673]
- Vanderbilt Medical Scientist Training Program [T32GM007347]
Landmark discoveries in the gut microbiome field have opened up new research avenues aimed at elucidating the impact of microbiota in colorectal cancer. An important challenge lies in determining the contribution of inherently variable environmental factors to carcinogenesis. Future research focused on unraveling host-microbe interactions in the colon may influence medical insights related to the prevention and treatment of colorectal cancer.
Landmark discoveries in the gut microbiome field have paved the way for new research aimed at illuminating the influence of microbiota in colorectal cancer. A major challenge is to account for the effect of inherently variable environmental factors on the host and the gut microbiome, while concurrently determining their contribution to carcinogenesis. Here, we briefly discuss the role of the gut microbial community in colorectal cancer and elaborate on the recent insight that environmental factors related to a Western diet and lifestyle may drive the bloom of tumorigenic members of the gut microbiota. We also discuss how future research focused on untangling host-microbe interactions in the colon may influence medical insights that relate to the prevention and treatment of colorectal cancer.
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