期刊
EXPERIMENTAL AND MOLECULAR PATHOLOGY
卷 102, 期 1, 页码 32-40出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yexmp.2016.11.006
关键词
Scorpion venom; Inflammatory response; Angiotensin II; Angiotensin converting enzyme; Angiotensin type-1 receptor; Cardiovascular system
类别
Scorpion stings are mainly associated with cardiovascular disturbances that may be the cause of death. In this study, the involvement of angiotensin II (Ang II) in cardiac and aortic inflammatory response was studied. Mice were injected with Androctonus australis hector (Aah) scorpion venom (0.5 mg/kg, subcutaneously), in the presence or absence of an angiotensin converting enzyme (ACE) inhibitor, captopril (15 mg/kg/day/1 day intraperitoneally) or an angiotensin type-1 receptor (AT1R) antagonist, valsartan (15 mg/kg/day/15 days, orally). In the envenomed group, results revealed severe tissue alterations with a concomitant increase of metabolic enzymes (CK and CK-MB) in sera. An important inflammatory cell (neutrophil and eosinophil) infiltration into the heart and aorta were observed, accompanied by imbalanced redox status (NO, MDA, catalase and GSH) and high cytokine levels (IL-6 and TNF-cc) in sera with the expression of MMP-2 and MMP-9 metalloproteinases. However, the blockade of the actions of Angll by the ACE inhibitor or by the AT1R antagonist prevented cardiac and aortic tissue alterations, inflammatory cell infiltration, as well as the oxidative stress generation and cytokine and metalloproteinase expression. These results suggest the involvement of Angll, through its AT1R in the inflammation induced by Aah venom, in the heart and the aorta. (C) 2016 Elsevier Inc. All rights reserved.
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