期刊
CURRENT OPINION IN TOXICOLOGY
卷 25, 期 -, 页码 30-35出版社
ELSEVIER
DOI: 10.1016/j.cotox.2021.03.002
关键词
Mercury; Methylmercury; Manganese; Heavy metal; Signaling pathways; Neurotoxicology
类别
资金
- National Institute of Environmental Health Sciences [NIEHS R01ES007331, R01ES10563]
Toxic and essential elements in the Earth's crust have significant impacts on human health, with the neurotoxic effects of methylmercury (MeHg) and manganese (Mn) being well recognized. Exposure to these elements can affect cell signaling pathways and contribute to molecular mechanisms of neurotoxicity.
Toxic and essential elements are widely distributed in the Earth's crust and individuals may be exposed to several of them. Indeed, exposure to toxic elements such as mercury (Hg) can be a potential health risk factor of health, mainly by ingestion of fish containing methylmercury (MeHg). On the other hand, essential elements such as manganese (Mn) play an important role in the physiological process in the human body; however, Mn overexposure may cause toxic effects. In this respect, the neurotoxic effects of MeHg and Mn on the developing brain are well recognized. Therefore, in this critical review, we address the effects of MeHg and Mn on cell signaling pathways, which may contribute to molecular mechanisms involved in MeHg-induced and Mn-induced neurotoxicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据