期刊
NANOSCALE
卷 13, 期 25, 页码 11250-11261出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr07981b
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资金
- National Natural Science Foundation of China [81874137]
- Outstanding Youth Foundation of Hunan Province [2018JJ1047]
- Hunan Province Science and Technology Talent Promotion Project [2019TJ-Q10]
- Key Research and Development Project of Hunan Province [2019NK2101]
- Natural Science Foundation Project of Changsha [kq2007063]
- Science and Technology Innovation Program of Hunan Province [2020RC4011]
- Young Scholars of Furong Scholar Program in Hunan Province
- Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hosipital of Central South University [BJ202001]
- Independent Exploration and Innovation Project of Central South University [2020zzts897]
Se@Albumin NPs, developed through self-assembly, significantly improved CDDP-induced intestinal mucositis in mouse models by regulating gut microbiota. Fecal microbiota transplantation from Se@Albumin NP-treated mice also provided significant protection against CDDP-induced intestinal mucositis in pseudo-aseptic mice.
Chemotherapy-associated intestinal mucositis is still one of the major challenges in the first-line clinical cancer treatment. Selenium element has shown health benefits on enteritis upon uptake in trace amounts; however, it was limited because of its narrow safety margin. In this work, a new form of Se@Albumin complex nanoparticles (Se@Albumin NPs) was developed by self-assembly of denatured human serum albumin and selenite salts. Se@Albumin NPs significantly improve intestinal mucositis induced with cisplatin (CDDP) in a mouse model via attenuating the level of intestinal oxidative stress, reducing intestinal permeability, and relieving gastric dysmotility. It is very interesting that the restoration of anti-inflammatory bacteria (Bacteroidetes and Firmicutes) and reduced abundance of proinflammatory bacteria (Escherichia) contributed to the reduction of intestinal mucositis by Se@Albumin NPs in mice. In addition, the fecal microbiota transplantation (FMT) with materials from Se@Albumin NP-treated mice significantly protected pseudo-aseptic mice from CDDP-induced intestinal mucositis. In conclusion, our findings showed that Se@Albumin NPs can significantly improve CDDP-induced intestinal mucositis, and its function may be directly mediated by gut microbiota regulation, which will provide new helpful information for clinical treatment.
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