期刊
SEMINARS IN NEPHROLOGY
卷 41, 期 2, 页码 104-113出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.semnephrol.2021.03.005
关键词
Diabetes mellitus; gut microbiome; prebiotics; probiotics
According to research, gut dysbiosis in diabetes mellitus may lead to decreased short-chain fatty acids and disruption of the epithelial barrier, resulting in systemic inflammation and insulin resistance. Gut dysbiosis is also associated with an increased risk of type 1 diabetes mellitus in children. Currently, some plant-based low protein diets and anti-diabetic drugs have been shown to have positive effects on the gut microbiome, but the effects of prebiotics and probiotics in clinical trials are still inconclusive.
Gut dysbiosis in diabetes mellitus is associated with decreased short-chain fatty acids and epithelial barrier disruption. Microbial-derived toxins move across the leaky gut and incur systemic inflammation and insulin resistance. In children, gut dysbiosis has been associated with risk of developing type 1 diabetes mellitus. In animal models, the obesity phenotype is transferable via microbiota transplantation. Plant-based low protein diets and cer-tain anti-diabetic drugs have been associated with positive microbiome effects. Clinical trials with prebiotics and pro-biotics have yielded mixed results. Further investigations are needed to evaluate the gut microbiome as a potential therapeutic target for diabetes prevention and management. (C) 2021 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据