期刊
TOXICOLOGY LETTERS
卷 348, 期 -, 页码 50-58出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2021.05.006
关键词
Antimony; Prostate cancer; PCA3; SREBP1; MIR-132-3P
类别
资金
- National Natural Science Foundation of China [81802568]
- Tianjin Municipal Science and Technology Project [20JCQNJC00530]
- Tianjin Health Science and Technology Project [KJ20169]
The study found that chronic exposure to antimony promotes cell growth and lipid metabolic disequilibrium in prostate cancer. The long noncoding RNA PCA3 plays a crucial role in regulating antimony-induced carcinogenesis by targeting the MIR-132-3 P/SREBP1 signaling pathway to promote antimony-induced lipid metabolic disorder.
Antimony is a common environmental contaminant that causes biological toxicity in exposed populations worldwide. Previous studies have revealed that antimony promotes prostate cancer growth by stabilizing the c-Myc protein and mimicking androgen activity. However, the role of lncRNAs in the regulation of antimony-induced carcinogenesis remains unknown, and the precise mechanisms need to be explored. In the present study, we found that chronic exposure to antimony promoted cell growth and lipid metabolic disequilibrium in prostate cancer. Mechanistically, we identified a long noncoding RNA molecule, PCA3, that was substantially upregulated in LNCaP cells in response to long-term antimony exposure. Functional studies indicated that abnormal PCA3 expression modulated antimony-induced proliferation and cellular triglyceride and cholesterol levels. In addition, PCA3 levels were found to be inversely correlated with MIR-132-3 P levels by acting as a decoy for MIR-132-3P. Besides, SREBP1 directly interacted with MIR-132-3 P to increase cell growth and disrupt lipid metabolism by targeting its 3'UTR regions. Taken together, our results revealed that lncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling. (c) 2021 Elsevier B.V. All rights reserved.
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