期刊
NON-CODING RNA
卷 7, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ncrna7020034
关键词
fission yeast; gametogenesis; gene expression; long non-coding RNAs; mitosis to meiosis transition
资金
- Agence Nationale de la Recherche [ANR-16-CE12-0031]
- Agence Nationale de la Recherche (ANR) [ANR-16-CE12-0031] Funding Source: Agence Nationale de la Recherche (ANR)
Long non-coding RNAs play a role in cell fate decisions by modulating genome expression and stability. In the fission yeast, specific lncRNAs shape cell cycle-dependent transcriptomes, influencing gametogenesis and contributing to meiosis-specific chromosomal events.
Long non-coding RNAs (lncRNAs) contribute to cell fate decisions by modulating genome expression and stability. In the fission yeast Schizosaccharomyces pombe, the transition from mitosis to meiosis results in a marked remodeling of gene expression profiles, which ultimately ensures gamete production and inheritance of genetic information to the offspring. This key developmental process involves a set of dedicated lncRNAs that shape cell cycle-dependent transcriptomes through a variety of mechanisms, including epigenetic modifications and the modulation of transcription, post-transcriptional and post-translational regulations, and that contribute to meiosis-specific chromosomal events. In this review, we summarize the biology of these lncRNAs, from their identification to mechanism of action, and discuss their regulatory role in the control of gametogenesis.
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