期刊
SIGNAL TRANSDUCTION AND TARGETED THERAPY
卷 6, 期 1, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41392-021-00686-1
关键词
-
资金
- National Key Research and Development Program of China [2020YFC0845500, 2018YFE0204500]
- Centrally Guided Hubei Provincial Science and Technology Development Fund Project [2020ZYYD012]
Our study on COVID-19 convalescent individuals showed that the survival of neutralizing antibodies is significantly affected by IL-2, IL-8, and IFN-gamma responses, while the activation of T cells and NK cells stimulated by antigen peptide pools is correlated with the presence of neutralizing antibodies. These findings provide insights into protective immunity against SARS-CoV-2, the pathogenesis of COVID-19, and the development of an effective vaccine.
We collected blood from coronavirus disease 2019 (COVID-19) convalescent individuals and investigated SARS-CoV-2-specific humoral and cellular immunity in these discharged patients. Follow-up analysis in a cohort of 171 patients at 4-11 months after the onset revealed high levels of IgG antibodies. A total of 78.1% (164/210) of the specimens tested positive for neutralizing antibody (NAb). SARS-CoV-2 antigen peptide pools-stimulated-IL-2 and -IFN-gamma response can distinguish COVID-19 convalescent individuals from healthy donors. Interestingly, NAb survival was significantly affected by the antigen peptide pools-stimulated-IL-2 response, -IL-8 response, and -IFN-gamma response. The antigen peptide pools-activated CD8+ T cell counts were correlated with NAb. The antigen peptide pools-activated natural killer (NK) cell counts in convalescent individuals were correlated with NAb and disease severity. Our data suggested that the development of NAb is associated with the activation of T cells and NK cells. Our work provides a basis for further analysis of the protective immunity to SARS-CoV-2 and for understanding the pathogenesis of COVID-19. It also has implications for the development of an effective vaccine for SARS-CoV-2 infection.
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