期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 45, 期 1, 页码 7-15出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000087
关键词
fitness; aerobic capacity; mitochondria; energy expenditure; obesity; hepatic steatosis; fat oxidation
资金
- NIDDK [R01DK088940]
- Biomedical Laboratory Research and Development of the U.S. Department of Veterans Affairs [1I01BX002567-01]
- American Heart Association Post Doctoral Research Award
Low-capacity runner (LCR) and high-capacity runner (HCR) rat strains are divergent for running capacity and aerobic fitness. The LCR rats are susceptible to obesity, insulin resistance, and fatty liver whereas the HCR are protected. We performed studies testing the hypothesis that the divergence in susceptibility for obesity and metabolic dysfunction between HCR/ LCR is due to differences in hepatic mitochondrial function that also may drive differences in energy expenditure and substrate usage.
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