期刊
EVOLUTIONARY APPLICATIONS
卷 11, 期 4, 页码 415-430出版社
WILEY
DOI: 10.1111/eva.12530
关键词
drug resistance; evolutionary medicine; insecticide resistance; malaria elimination; resistance management strategies
资金
- Society in Science - Branco Weiss Fellowship
- Bill and Melinda Gates Foundation
- Obra Social la Caixa Partnership for the Elimination of Malaria in Southern Mozambique [OPP1115265]
- Bill and Melinda Gates Foundation [OPP1115265] Funding Source: Bill and Melinda Gates Foundation
Since 2000, the world has made significant progress in reducing malaria morbidity and mortality, and several countries in Africa, South America and South-East Asia are working hard to eliminate the disease. These elimination efforts continue to rely heavily on antimalarial drugs and insecticide-based interventions, which remain the cornerstones of malaria treatment and prevention. However, resistance has emerged against nearly every antimalarial drug and insecticide that is available. In this review we discuss the evolutionary consequences of the way we currently implement antimalarial interventions, which is leading to resistance and may ultimately lead to control failure, but also how evolutionary principles can be applied to extend the lifespan of current and novel interventions. A greater understanding of the general evolutionary principles that are at the core of emerging resistance is urgently needed if we are to develop improved resistance management strategies with the ultimate goal to achieve a malaria-free world.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据