Iron-catalyzed alkylation of carbazole derivatives via hydroarylation of styrenes

The first direct and selective 3,6-di-alkylation of carbazoles via iron-catalyzed hydroarylation of styrenes is demonstrated. This simple, general and efficient method could deliver a wide range of di-benzyl-carbazoles with high chemo- and regio-selectivity at room temperature in up to 96% yield with no need for a noble-metal catalyst, directing group or additives.

Automated summary

This study demonstrates the first direct and selective 3,6-di-alkylation of carbazoles through iron-catalyzed hydroarylation of styrenes. The method is simple, general, and efficient, delivering a wide range of di-benzyl-carbazoles in up to 96% yield at room temperature without the need for a noble-metal catalyst, directing group, or additives.