期刊
MATERIALS HORIZONS
卷 8, 期 8, 页码 2273-2285出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1mh00492a
关键词
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资金
- National Natural Science Foundation of China [32071322, 81801826, 31922042, 81771966]
- Technology & Innovation Commission of Shenzhen Municipality [JCYJ20180307153300735, JCYJ20180507181654186, JCYJ20170818162637217]
- Fundamental Research Funds for the Central Universities [2020-RC320-002, 2019PT320028]
The piezo-photocatalytic therapy utilizing thermally treated natural sphalerite nanosheet heterojunction efficiently induced intracellular ROS burst and apoptosis of cancer cells by minimizing charge recombination and leading to high-performance radical generation and GSH depletion.
A piezo-photocatalytic therapy based on thermally treated natural sphalerite nanosheet (NSH700 NS) heterojunction was applied to efficiently induce intracellular ROS burst and apoptosis of cancer cells. Upon ultrasound and laser irradiation, the formation of a polarized electric field and band bending of NSH700 NSs allow the directional separation of charges both in the bulk and their interface, thereby minimizing the probability of charge recombination. The piezo-photocatalytic effect leads to an efficient catalytic performance, exhibiting high-performance superoxide radical (O-2(-)) and hydroxyl radical (OH) generation and glutathione (GSH) depletion, which results in a intracellular ROS burst-triggered apoptosis of cancer cells both in vitro and in vivo.
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