The Emerging Role of the Interactions between Circular RNAs and RNA-binding Proteins in Common Human Cancers

Circular RNAs (circRNAs) are a unique family of noncoding RNAs that could regulate multiple biological processes, which play a crucial role in carcinogenesis, progression and chemotherapy resistance of cancers. Growing studies have demonstrated that circRNAs act as novel biomarkers and therapeutic targets for cancers by sponging microRNAs (miRNAs). Up to date, another function of circRNAs, combining with RNA-binding proteins (RBPs), was uncovered. However, there is limit studies illustrating the underlying mechanism of circRNAs-RBPs interactions, as well as showing its roles in diverse types of cancers. In this review, we collected the biogenesis, properties of circRNAs, and then synthesize the connection between circRNAs and RBPs, and try to clarify its molecular mechanisms involving in the pathogenesis and progression of several common cancers, aiming to provide a brand-new insight to the prognosis and treatment strategy for cancers.

Automated summary

circRNAs are a unique family of noncoding RNAs that can regulate multiple biological processes and play a crucial role in the carcinogenesis and development of cancers by sponging miRNAs. In addition to sponging miRNAs, circRNAs also interact with RBPs to exert their functions, but studies on the underlying mechanisms and roles in different cancers are limited.