4.7 Article

Acoustic valves in microfluidic channels for droplet manipulation

期刊

LAB ON A CHIP
卷 21, 期 16, 页码 3165-3173

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1lc00261a

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资金

  1. National Key Research and Development Program of China [2020YFB2009002]
  2. National Natural Science Foundation of China [52075432]
  3. Program for Innovation Team of Shaanxi Province [2021TD-23]
  4. State Key Laboratory for Manufacturing Systems Engineering [sklms2017006]

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The novel concept of acoustic valves in microfluidic channels uses focused acoustic fields to control droplets, eliminating the need for high voltage or sample modification. This non-contact manipulation method is suitable for biochemical experiments with minimal requirements, especially those involving optical observation and chemical reactions.
A novel concept of using acoustic valves in microfluidic channels is reported in this work for the first time. An acoustic valve is a controllable virtual barrier constructed with focused acoustic fields, which can control droplets into different branch channels or block and then release them to specific target channels. Compared with other droplet sorting devices using a surface acoustic wave, acoustic valves do not use an acoustic field to drive droplets but only block branch channels. Compared with other sorting methods, such as using dielectric and magnetic forces, acoustic valves do not need a high voltage or target sample modification. As a non-contact and low-damage manipulation method with minimal requirements for target samples, the use of acoustic valve is suitable for microfluidic applications like sorting and manipulation in biochemical experiments, especially those involving optical observation, fluorescence testing, and chemical reactions.

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