4.6 Article

Structures and absolute configurations of phomalones from the coral-associated fungus Parengyodontium album sp. SCSIO 40430

期刊

ORGANIC & BIOMOLECULAR CHEMISTRY
卷 19, 期 27, 页码 6030-6037

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob00869b

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资金

  1. MOST [2019YFC0312503, 2018YFC1406704]
  2. NSFC [41676165, 41906100, 81973372]
  3. K. C. Wong Education Foundation [GJTD-2020-12]
  4. Chinese Academy of Sciences [QYZDJ-SSW-DQC004, 154144KYSB20190005]
  5. special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]
  6. Guangdong Province [GDME-2018C005]
  7. Guangdong Provincial Special Fund for Marine Economic Development Project [[2020]032]
  8. Guangxi Province [GXMNOC2020007]

向作者/读者索取更多资源

Coral-associated microorganisms may produce antimicrobials that play a role in host defense. Six new chromanones and ten known analogues were isolated from the coral-associated fungus Parengyodontium album sp. SCSIO 40430, with some compounds showing activity against Mycobacterium tuberculosis H37Ra.
Coral-associated microorganisms are likely to play an important role in host defense by the production of antimicrobials. Six new chromanones, namely, phomalichenones H-M (5, 6, and 8-11), and ten known analogues (1-4, 7, and 12-16) were isolated from the coral-associated fungus Parengyodontium album sp. SCSIO 40430. Their structures were elucidated by comprehensive spectroscopic analyses. In addition, the structure of 8 was confirmed by X-ray crystallographic analysis. Resolution using a chiral column showed that each of the compounds 1-8 was an enantiomeric mixture with variable enantiomeric excess (ee) values. Their absolute configurations were determined by a comparison of the experimental and calculated ECD data and by a modified Mosher's method. A plausible biosynthetic scheme was proposed for the production of 1-16. Compounds 2, 3, 13, and 14 were found to be active against Mycobacterium tuberculosis H37Ra with MIC values of 16-64 mu g mL(-1).

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