Reversible regulation of metallo-base-pair interactions for DNA dehybridization by ultrasound

Mechanical force applied by ultrasound in solution leads to the dissociation of DNA metallo-base-pair interactions when these motifs are functionalized with oligodeoxynucleotide sequences of sufficient length. The annealing and force-induced denaturing process is followed by the attachment of distance-sensitive fluorescent probes and is found to be reversible.

Automated summary

Ultrasound-induced mechanical force leads to dissociation of DNA metallo-base-pairs when functionalized with long enough oligodeoxynucleotide sequences. The subsequent attachment of distance-sensitive fluorescent probes following the annealing and force-induced denaturing process is reversible.