期刊
NEW JOURNAL OF CHEMISTRY
卷 45, 期 29, 页码 13056-13063出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nj01356d
关键词
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资金
- National Natural Science Foundation of China [21774060]
- National Key R&D Program of China [2017YFF0207804]
- Jiangsu Key Lab of Biomass-based Energy and Materials [JSBEM2016011]
- State Key Laboratory for Mechanical Behavior of Materials [20171914]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP)
- Natural Science Key Project of the Jiangsu Higher Education Institutions [16KJA220006]
The development of a temperature-responsive tailorable fibrous localized drug-delivery system allows for subtle control of release profiles by tuning the mass fraction, and experimental results confirm that media released at 39 degrees C is more effective in killing cancer cells compared to those released below 39 degrees C.
Localized intelligent drug delivery systems (IDDSs) are promising platforms for solid tumor therapy with lower toxicity to physiological systems and improved curative effects due to efficiently controlled site-specific delivery of therapeutic molecules. To this end, a temperature-responsive tailorable fibrous localized drug-delivery system with enhanced mechanical properties to withstand the stress in vivo and temporal loading regimes for cancer treatment is developed. A series of PCM-functionalized PU-PCL core-shell fiber mats are prepared by coaxial electrospinning, which exhibit a tunable temperature response and controlled release capability. The in vitro release profiles observably show faster release of encapsulated molecules above 39 degrees C than that at lower temperatures under the same conditions and the study proves that the release conforms to biphasic release kinetics. The release profiles could be subtly regulated via tuning the mass fraction of the PCM. More importantly, the result of cytotoxicity assay shows the viability of cancer cells after treatment with hydroxycamptothecin (HCPT) release media at different temperatures and indicates that media containing HCPT released at 39 degrees C could kill significantly more cancer cells than those released below 39 degrees C, which confirms the temperature sensitivity of the prepared IDDSs. This work thus provides a promising intelligent platform for site-specific drug-delivery in solid tumor therapy.
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