Recent advances and prospects in the iron-catalyzed trifluoromethylation reactions

The development of effective methods to create a C-CF3 bond has attracted great attention in organofluorine chemistry and also in homogeneous catalysis. Recently, iron-catalyzed trifluoromethylation reactions have progressed widely to produce numerous CF3-containing compounds. In current years, with the arrival of transition metal-catalyzed trifluromethylation reactions, iron-catalyzed reactions are recognized to be promising for providing extremely functionalized products. This review provides an overview of the Fe-catalyzed trifluoromethylation reactions leading to the formation of various types of compounds such as amines, acids, aldehydes, ketones etc. covering the literature up to 2020.

Automated summary

The development of iron-catalyzed trifluoromethylation reactions has attracted significant attention for producing a variety of CF3-containing compounds. The method is recognized as promising for providing highly functionalized products.