Micelle enabled C(sp2)-C(sp3) cross-electrophile coupling in water via synergistic nickel and copper catalysis

A robust and sustainable C(sp(2))-C(sp(3)) cross-electrophile coupling was developed via nickel/copper synergistic catalysis under micellar conditions. This protocol provided a general method to access alkylated arenes with good to excellent yields on a very large scale.

Automated summary

A robust and sustainable C(sp(2))-C(sp(3)) cross-electrophile coupling was successfully achieved under micellar conditions using nickel/copper synergistic catalysis, providing a general method to access alkylated arenes with good to excellent yields on a very large scale.