期刊
CURRENT SCIENCE
卷 120, 期 12, 页码 1820-1826出版社
INDIAN ACAD SCIENCES
DOI: 10.18520/cs/v120/i12/1820-1826
关键词
Coronavirus; gain of function research; SARS-CoV-2; spike protein sequences
The ongoing debate about the origins of the SARS-CoV-2 coronavirus revolves around the controversial hypothesis that it emerged through natural zoonotic transfer rather than laboratory leakage. Research suggests that gain of function research methods could pose a potential public health threat in the event of laboratory leaks.
There is currently an ongoing debate on the origins of the SARS-CoV-2 coronavirus, the causative agent of the COVID-19 pandemic. The hypothesis that the virus emerged as a result of natural zoonotic transfer has been controversially questioned, on the basis of unusual sequence signatures in the spike protein and the absence of evidence for an intermediate animal host. This article briefly surveys the background to coronavirus research and addresses the development of the methods of gain of function research, which have been suggested to be a potential public health threat in the event of laboratory leakage.
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