Iron-catalysed enantioselective carbometalation of azabicycloalkenes

The first enantioselective carbometalation reaction of azabicycloalkenes has been achieved by iron catalysis to in situ form optically active organozinc intermediates, which are amenable to further synthetic elaborations. The observed chiral induction, along with the DFT and XAS analyses, reveals the direct coordination of the chiral phosphine ligand to the iron centre during the carbon-carbon and carbon-metal bond forming step. This new class of iron-catalysed asymmetric reaction will contribute to the synthesis and production of bioactive molecules.

Automated summary

The first enantioselective carbometalation reaction of azabicycloalkenes has been achieved by iron catalysis to form optically active organozinc intermediates, showing the direct coordination of the chiral phosphine ligand to the iron center during bond formation. This new class of iron-catalyzed asymmetric reaction will contribute to the synthesis and production of bioactive molecules.