期刊
LAB ON A CHIP
卷 21, 期 16, 页码 3076-3085出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1lc00239b
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- Japan Society for the Promotion of Science (JSPS) KAKENHI [18H01846]
- Grants-in-Aid for Scientific Research [18H01846] Funding Source: KAKEN
The study focused on the controlled movements of single nanoparticles passing through an octet nanochannel for accurate zeta-potential assessments, revealing an exponential decrease in translocation duration between channels. This finding allows for precise estimation of single-nanoparticle zeta potential and provides a useful tool for analyzing particles and molecules of variable sizes.
Capture-to-translocation dynamics control is an important issue for single-particle and -molecule analyses by resistive pulse waveforms. Here, we report on regulated motions for accurate zeta-potential assessments of single nanoscale objects passing through an octet-nanochannel. We observed ionic spike signals consisting of eight consecutive sub-pulses signifying the ion blockage at the eight sensing zones in series upon electrophoretic translocation of individual nanoparticles. We find an exponential decrease to saturation of the channel-to-channel translocation duration as a nanobead moves forward, reflecting the more restricted radial motion degrees of freedom via inertial effects at the downstream side of the octet channel. This finding enabled a protocol for single-nanoparticle zeta potential estimation impervious to the uncertainty stemming from the stochastic nature of the translocation dynamics. The multi-channel approach presented in this study may be used as a useful tool for analyzing particles and molecules of variable sizes.
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