Room-temperature controllable synthesis of hierarchically flower-like hollow covalent organic frameworks for brain natriuretic peptide enrichment

A facile strategy was introduced for room-temperature controllable synthesis of hierarchically flower-like hollow COFs (FHF-COFs). Furthermore, the universality for synthesis of the HFH-COFs was validated by altering the building units. Inspired by the unique morphology, extremely large surface area and good chemical stability, HFH-COFs could serve as an attractive adsorption probe by loading with gold nanoparticles and be applied to enrichment of brain natriuretic peptide from human serum. This work opens up a whole new approach for controllable synthesis of the HFH-COFs at room temperature and expands the application of COFs as a promising enrichment probe for complex biological samples.

Automated summary

A facile strategy for room-temperature controllable synthesis of hierarchically flower-like hollow COFs was introduced, with the universality for synthesis validated by altering the building units. The unique morphology and properties of HFH-COFs make them promising for enrichment in biological samples, such as brain natriuretic peptide from human serum, by loading with gold nanoparticles. This work opens up a new approach for synthesis of HFH-COFs and expands their application as enrichment probes for complex biological samples.