期刊
ORGANIC CHEMISTRY FRONTIERS
卷 8, 期 17, 页码 4860-4864出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo00542a
关键词
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资金
- National Natural Science Foundation of China [21861007, 21702034]
- Natural Science Foundation of Guangxi Province [2021GXNSFAA075024, 2017GXNSFBA198089]
- BAGUI Scholar Program of Guangxi Province of China
- 2018 Graduate Education Innovation Plan Project [602021624]
A tunable synthesis of chalcophosphinic amides and phosphinates was achieved through a copper-catalyzed reaction. The tert-butyl N,N-dialkylperoxyamidate played a dual role in this transformation without requiring additional oxidants, bases, or additives. The products were obtained under different catalytic conditions, offering a new approach to difficult-to-access compounds.
The tunable synthesis of chalcophosphinic amides and phosphinates via a copper-catalyzed reaction between phosphine chalcoxides and tert-butyl N,N-dialkylperoxyamidate has been developed. tert-Butyl N,N-dialkylperoxyamidate plays a dual role as a secondary amine and a tertiary alcohol precursor in this transformation, without the need for additional oxidants, bases or other additives. Chalcophosphinic amides were accessed under catalysis with CuI in CH2Cl2, while tert-butyl chalcophosphinates were generated with the aid of catalytic Cu(OAc)(2) in THF, which were difficult to obtain by previous methods.
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