Serosurvey in BNT162b2 vaccine-elicited neutralizing antibodies against authentic B.1, B.1.1.7, B.1.351, B.1.525 and P.1 SARS-CoV-2 variants

In this study, we show that BNT162b2 vaccine-elicited antibodies efficiently neutralize SARS-CoV-2 authentic viruses belonging to B.1, B.1.1.7, B.1.351, B.1.525 and P.1 lineages. Interestingly, the neutralization of B.1.1.7 and B.1.525 lineages was significantly higher, whereas the neutralization of B.1.351 and P.1 lineages was robust but significantly lower as compared to B.1 lineage. Following our findings, we consider that the BNT162b2 vaccine offers protection against the current prevailing variants of SARS-CoV-2.

Automated summary

The study demonstrates that antibodies generated by the BNT162b2 vaccine can efficiently neutralize authentic viruses belonging to various SARS-CoV-2 lineages. Neutralization was highest for B.1.1.7 and B.1.525 lineages, while lower for B.1.351 and P.1 lineages compared to the B.1 lineage. The findings suggest that the BNT162b2 vaccine offers protection against the prevailing variants of SARS-CoV-2.