期刊
TZU CHI MEDICAL JOURNAL
卷 33, 期 3, 页码 203-211出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/tcmj.tcmj_162_20
关键词
Breast cancer; Cytokine; Interleukin-10; Tumor microenvironment
资金
- Tzu Chi University [TCMRC-P-108010]
Breast cancer is categorized into different subgroups based on hormone receptors, each requiring different treatment strategies. Cytokines play a vital role in tumor growth, metastasis, and resistance to treatment, with IL-10 acting as an immunoregulatory cytokine and a poor prognostic marker in many cancers.
Breast cancer (BC) is a frequently diagnosed cancer among women worldwide. Currently, BC can be divided into different subgroups according to the presence of the following hormone receptors: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Each of these subgroups has different treatment strategies. However, the presence of new metastatic lesions and patient deterioration suggest resistance to a given treatment. Various lines of evidence had shown that cytokines are one of the important mediators of tumor growth, invasion, metastasis, and treatment resistance. Interleukin-10 (IL-10) is an immunoregulatory cytokine, and acts as a poor prognostic marker in many cancers. The anti-inflammatory IL-10 blocks certain effects of inflammatory cytokines. It also antagonizes the co-stimulatory molecules on the antigen-presenting cells. Here, we review the current knowledge on the function and molecular mechanism of IL-10, and recent findings on how IL-10 contributes to the progression of BC.
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