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Dual targeting of TAM receptors Tyro3, Axl, and MerTK: Role in tumors and the tumor immune microenvironment

期刊

TZU CHI MEDICAL JOURNAL
卷 33, 期 3, 页码 250-256

出版社

WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/tcmj.tcmj_129_20

关键词

Axl; MerTK; Tyro3; Axl; and MerTK receptors; Tumor immune microenvironment; Tyro3

资金

  1. Buddhist Tzu Chi Medical Foundation [EP-108-02]

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This article discusses the expression of RTKs in normal and tumor tissues, the pleiotropic role of the TAM family of RTKs in cellular activities, their roles in cancer and immune cells, and cancer therapies targeting TAM receptors. Further research is needed to understand the function of TAM receptors in immune cells for developing new targeted immunotherapies for cancer.
In both normal and tumor tissues, receptor tyrosine kinases (RTKs) may be pleiotropically expressed. The RTKs not only regulate ordinary cellular processes, including proliferation, survival, adhesion, and migration, but also have a critical role in the development of many types of cancer. The Tyro3, Axl, and MerTK (TAM) family of RTKs (Tyro3, Axl, and MerTK) plays a pleiotropic role in phagocytosis, inflammation, and normal cellular processes. In this article, we highlight the cellular activities of TAM receptors and discuss their roles in cancer and immune cells. We also discuss cancer therapies that target TAM receptors. Further research is needed to elucidate the function of TAM receptors in immune cells toward the development of new targeted immunotherapies for cancer.

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