Applications of aryl-sulfinamides in the synthesis of N-heterocycles

Enantiopure aryl-sulfinamides are important chiral auxiliaries in the asymmetric synthesis of amines and their derivatives. Here, we provide an overview of arylsulfinamide mediated asymmetric methods towards N-heterocycle synthesis. This methodology through sulfinylimines offers general access to structurally diverse piperidines, pyrrolidines, aziridines and their derivatives which represent the structural motif of many natural products and therapeutically important compounds. The review covers articles from 2006-2020 and we have categorized the review based on the ring size as 3-, 5-, and 6- membered heterocycles and their derivatives.

Automated summary

This review summarizes the application of enantiopure aryl-sulfinamides in asymmetric methods for N-heterocycle synthesis, providing a general pathway to diverse piperidines, pyrrolidines, aziridines, and their derivatives through sulfinylimines.