4.7 Review

Biosynthesis of azaphilones: a review

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Summary: The study investigated the diversity of azaphilones in stromatal extracts of the fungus Hypoxylon fragiforme and linked them to their biosynthetic machineries through bioinformatics. It identified four unprecedented bis-azaphilones and a hybrid azaphilone with strong inhibition of Staphylococcus aureus biofilm formation. Genome analysis revealed two separate biosynthetic gene clusters responsible for azaphilone formation, representing the first example of distant cross-acting fungal BGCs collaborating to produce different families of azaphilones.

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