4.6 Article

Diaryl azo derivatives as anti-diabetic and antimicrobial agents: synthesis, in vitro, kinetic and docking studies

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Synthesis, crystal structure and Hirshfeld Surface analysis of benzamide derivatives of thiourea as potent inhibitors of α-glucosidase in-vitro

Sidra Akhter et al.

Summary: The benzamide-based structural analogues showed potent inhibition of alpha-glucosidase, with most compounds being non-cytotoxic and demonstrating significant DPPH radical scavenging activity. Compound 9 exhibited cytotoxicity against 3T3 normal mouse fibroblast cell lines. Mode of enzyme inhibition was determined for some compounds based on kinetic studies.

BIOORGANIC CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Design and synthesis of novel pyrazole-phenyl semicarbazone derivatives as potential α-glucosidase inhibitor: Kinetics and molecular dynamics simulation study

Fateme Azimi et al.

Summary: A series of novel pyrazole-phenyl semicarbazone derivatives were synthesized and tested for in vitro alpha-glucosidase inhibitory activity, with compound 8o showing the most potent inhibitory activity. Pharmacophore modification and molecular dynamic simulations supported the rational design and provided insights into the dynamic behavior and structural changes in the systems.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Chemistry, Physical

Synthesis and characterization of novel bioactive azo compounds fused with benzothiazole and their versatile biological applications

Shanmugam Prakash et al.

Summary: This study successfully synthesized novel azo compounds with potent antioxidant and antibacterial activities, as well as positive outcomes in anticancer and toxicity evaluations.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Article Chemistry, Physical

Synthesis and biological evaluation of new dihydroindolizino[8,7-b]indole derivatives as novel α-glucosidase inhibitors

Fariba Peytam et al.

Summary: Eighteen dihydroindolizino[8,7b]indole derivatives were designed, synthesized, and evaluated as new alpha-glucosidase inhibitors. Among them, diethyl derivative 4o and dimethyl derivative 4 h exhibited the highest anti-alpha-glucosidase activities. Docking studies showed that these compounds interacted with important residues in the active site of alpha-glucosidase.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Article Biochemistry & Molecular Biology

A new biological prospective for the 2-phenylbenzofurans as inhibitors of α-glucosidase and of the islet amyloid polypeptide formation

Giovanna Lucia Delogu et al.

Summary: The study found that hydroxylated 2-phenylbenzofurans compounds exhibited strong inhibitory activity against alpha-glucosidase, with compound 16 showing the best performance. It also effectively inhibited IAPP aggregation without significant cytotoxicity.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Chemistry, Physical

Synthesis, characterization and computational study on potential inhibitory action of novel azo imidazole derivatives against COVID-19 main protease (Mpro: 6LU7)

Abhijit Chhetri et al.

Summary: This study demonstrated the synthesis and characterization of a series of novel imidazole anchored azo-imidazole derivatives, as well as their inhibitory effects against the Main Protease of SARS-CoV2. The docking studies showed significant binding energy values for the ligands, indicating potential antiviral activity. Pharmacokinetic properties of the ligands were also investigated.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Article Immunology

Antimicrobial resistance in Escherichia coli isolates from frugivorous (Eidolon helvum) and insectivorous (Nycteris hispida) bats in Southeast Nigeria, with detection of CTX-M-15 producing isolates

Lynda O. Obodoechi et al.

Summary: The study investigated the antimicrobial resistance of Escherichia coli isolates from 180 bats, revealing potential threats such as multidrug-resistant isolates and ESBL-producing strains. Additionally, virulence gene detection and molecular typing were conducted on some isolates.

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES (2021)

Article Chemistry, Applied

Synthesis, characterization and antimicrobial activity of some new azo dyes derived from 4-hydroxy-6-methyl-2H-pyran-2-one and its dihydro derivative

Soumaya Ben Mohamed-Smati et al.

Summary: A series of new azo disperse dyes were synthesized by coupling different diazonium salts with 4-hydroxy-6-methyl-2H-pyran-2-one (TAL) or its derivative DHTAL. The spectroscopic data and antibacterial activity of these dyes in various solvents were investigated. Structural confirmation was done using various analytical techniques, and in vitro antibacterial activity was qualitatively and quantitatively assessed against both Gram positive and Gram negative bacteria.

DYES AND PIGMENTS (2021)

Article Chemistry, Applied

Comparative study of inhibition mechanisms of structurally different flavonoid compounds on α-glucosidase and synergistic effect with acarbose

Jichen Yang et al.

Summary: Flavonoid compounds have anti-diabetic activity by controlling blood glucose levels through inhibiting the activity of alpha-glucosidase. The study showed that these compounds had higher inhibitory activities compared to acarbose, with scutellarein potentially serving as the most effective inhibitor. Additionally, the synergistic effects of flavonoid compounds combined with acarbose on alpha-glucosidase activity were observed.

FOOD CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Dihydropyridines as potential α-amylase and α-glucosidase inhibitors: Synthesis, in vitro and in silico studies

Hina Yousuf et al.

BIOORGANIC CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Novel N-Acyl-1H-imidazole-1-carbothioamides: Design, Synthesis, Biological and Computational Studies

Hamid Aziz et al.

CHEMISTRY & BIODIVERSITY (2020)

Article Chemistry, Physical

Synthesis, characterization and pharmacological evaluation of 2-aminothiazole incorporated azo dyes

B. N. Ravi et al.

JOURNAL OF MOLECULAR STRUCTURE (2020)

Article Multidisciplinary Sciences

A new sulphur containing heterocycles having azo linkage: Synthesis, structural characterization and biological evaluation

Mallikarjuna Niluvanji Matada et al.

JOURNAL OF KING SAUD UNIVERSITY SCIENCE (2020)

Article Chemistry, Physical

Synthesis, bioactivities, DFT and in-silico appraisal of azo clubbed benzothiazole derivatives

Chaitannya W. Ghanavatkar et al.

JOURNAL OF MOLECULAR STRUCTURE (2019)

Article Chemistry, Medicinal

Phenolic N-monosubstituted carbamates: Antitubercular and toxicity evaluation of multi-targeting compounds

Martin Kratky et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Chemistry, Applied

Facile synthesis of novel disperse azo dyes with aromatic hydroxyl group

Jinjing Qiu et al.

DYES AND PIGMENTS (2019)

Article Chemistry, Medicinal

Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors

Jianjun Yu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Competitive α-glucosidase inhibitors, dihydrobenzoxanthones, from the barks of Artocarpus elasticus

Janar Jenis et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2019)

Article Mathematical & Computational Biology

Exploration of Novel Human Tyrosinase Inhibitors by Molecular Modeling, Docking and Simulation Studies

Mubashir Hassan et al.

INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES (2018)

Article Public, Environmental & Occupational Health

In vitro, in vivo and in silico anti-hyperglycemic inhibition by sinigrin

Qamar Abbas et al.

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE (2017)

Article Biochemical Research Methods

MolProbity: all-atom structure validation for macromolecular crystallography

Vincent B. Chen et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Article Chemistry, Medicinal

Synthesis of diaryl-azo derivatives as potential antifungal agents

Hui Xu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

VADAR: a web server for quantitative evaluation of protein structure quality

L Willard et al.

NUCLEIC ACIDS RESEARCH (2003)

Article Biochemistry & Molecular Biology

Structure validation by Cα geometry:: φ,ψ and Cβ deviation

SC Lovell et al.

PROTEINS-STRUCTURE FUNCTION AND GENETICS (2003)