Recent developments in the synthesis of polysubstituted pyridines via multicomponent reactions using nanocatalysts

The synthesis of heterocyclic compounds containing a bioactive core including the pyridine molecular framework with diverse pharmaceutical and biological activities is noteworthy. Recently chemists have created novel active pharmacophores via MCRs in the presence of nanocatalysts. The application of various types of nanoparticles as catalysts has been studied in the formation of polyfunctionalized pyridines via multicomponent reactions, and is the subject of this review, which concentrates on their application for the synthesis of pyridine derivatives by multicomponent reactions in the last decade (2010-2020).

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This review focuses on the application of various types of nanoparticles as catalysts in the synthesis of pyridine derivatives via multicomponent reactions in the past decade (2010-2020), demonstrating the creation of novel active pharmacophores by chemists.