期刊
JOURNAL OF CANCER
卷 12, 期 8, 页码 2412-2421出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.52426
关键词
Gastric cancer; SCARA5; proliferation; migration and invasion; EMT
类别
资金
- National Science Foundation of China [81802474]
- Natural Scientific Foundation of Shandong Province [ZR2015HL091]
- Weifang Medical University
SCARA5 expression is downregulated in gastric cancer, associated with promoter methylation, aggressive clinicopathological characteristics, and poor prognosis. Overexpression of SCARA5 inhibits the growth and migration of GC cells, potentially serving as a biomarker for diagnosis and therapeutic target.
Scavenger receptor class A member 5 (SCARA5) has been reported to be implicated in several types of cancer. However, its biological roles and mechanism of SCARA5 in gastric cancer (GC) have not been elucidated. In the present study, SCARA5 expression was found to be downregulated in GC which was associated with promoter methylation. The protein level of SCARA5 was negatively associated with aggressive clinicopathological characteristics, as well as poor prognosis. Moreover, SCARA5 overexpression markedly suppressed the growth, migration and invasion of GC cell lines in vitro. Furthermore, upregulation of SCARA5 inhibited gastric tumor growth and metastasis in a xenograft model. Mechanistic analysis revealed that SCARA5 suppressed the migration and invasion of GC cells via inhibiting epithelial-mesenchymal transition (EMT) and inactivating MMP-2 and MMP-9. Taken together, these results demonstrated that SCARA5 might play vital roles in the GC genesis and progression and could serve as a potential biomarker for diagnosis and therapeutic target of GC.
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