期刊
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
卷 11, 期 4, 页码 511-514出版社
ELSEVIER - DIVISION REED ELSEVIER INDIA PVT LTD
DOI: 10.1016/j.jceh.2020.09.002
关键词
peripheral T-cell lymphoma not otherwise specified; liver transplantation; Epstein-Barr virus; chemotherapy; remission
PTLD, a rare complication after liver transplant, commonly involves B-cell subtype associated with EBV infection, while T-cell subtype is even rarer. This case presents a 21-year-old patient with peripheral T-cell lymphoma associated with EBV infection, achieving remission after standard chemotherapy.
Introduction: Posttransplant lymphoproliferative disorder (PTLD) is a rare complication seen in the period after liver transplant. The commonest subtype is B-cell PTLD which is usually associated with Epstein-Barr virus (EBV) infection. T-cell PTLD is rare and the association with EBV is again rarer. Case: Our patient, a 21-yearold young adult, presented to us with generalized lymphadenopathy, 5 years after liver transplantation. The biopsy of the lymph node was suggestive of peripheral T-cell lymphoma not otherwise specified, which was associated with EBV infection. The Positron emission tomography and computerised tomography (PET-CT) scan showed stage 3 disease. He was treated with standard cyclophosphamide, doxorubicin, etoposide, vincristine, and prednisolone chemotherapy and is currently in remission. Conclusion: Peripheral T-cell lymphoma not otherwise specified is a rare subtype of PTLD and its association with EBV is even more rare. A few patients can achieve complete remission with standard chemotherapy.
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