期刊
EMERGING INFECTIOUS DISEASES
卷 27, 期 6, 页码 1637-1644出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2706.204323
关键词
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资金
- National Institute of Allergy and Infectious Diseases [R01 GM083224]
- Military Infectious Diseases Program
- Armed Forces Health Surveillance Branch and its Global Emerging Infections Surveillance Section
Researchers used phylogenomic analysis to study household transmissions of dengue virus in Kamphaeng Phet, Thailand, finding that on average, dengue disperses 70 meters per day between households in the community. This approach provides a framework for public health tools to inform control approaches and track dengue transmissions accurately.
Dengue control approaches are best informed by granular spatial epidemiology of these viruses, yet reconstruction of inter- and intra-household transmissions is limited when analyzing case count, serologic, or genomic consensus sequence data. To determine viral spread on a finer spatial scale, we extended phylogenomic discrete trait analyses to reconstructions of house-to-house transmissions within a prospective cluster study in Kamphaeng Phet, Thailand. For additional resolution and transmission confirmation, we mapped dengue intra-host single nucleotide variants on the taxa of these time-scaled phylogenies. This approach confirmed 19 household transmissions and revealed that dengue disperses an average of 70 m per day between households in these communities. We describe an evolutionary biology framework for the resolution of dengue transmissions that cannot be differentiated based on epidemiologic and consensus genome data alone. This framework can be used as a public health tool to inform control approaches and enable precise tracing of dengue transmissions.
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