4.7 Article

Effects of Stimulating Local and Distal Acupoints on Diabetic Gastroparesis: A New Insight in Revealing Acupuncture Therapeutics

期刊

AMERICAN JOURNAL OF CHINESE MEDICINE
卷 49, 期 5, 页码 1151-1164

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WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X21500555

关键词

Local and Distal Acupoints; Acupoints Combination; SPECT-CT; Gastric Motility; nNOS

资金

  1. National Basic Research Program of China [2014CB543100]

向作者/读者索取更多资源

The study on diabetic gastroparesis rats treated with acupuncture at Zhongwan and Zusanli points showed that different acupoints stimulation had different therapeutic effects, while needling local and distal acupoints together may have antagonistic or synergistic effects on gastric motility, ghrelin, gastrin, and growth factor 1.
One of the most important aspects of clinical acupuncture practice, like diabetic gastroparesis, is the selection of suitable acupoints. Furthermore, it is critical to examine the therapeutic impact differences between distal and local acupoints, as well as the prescription of their combination. In this study, diabetic gastroparesis rats were treated by needling Zhongwan (CV12) and Zusanli (ST36), and then used Single Photon Emission Computed Tomography-CT (SPECT-CT) technology to assess the effects of promoting gastric motility. In addition, morphological observation, immunohistochemical examination, and biomarker assays, such as determination of growth factor 1, motilin, and ghrelin contents in serum samples, were performed to better understand the impact of certain various acupuncture treatments. All of the therapies improved the symptoms of diabetic gastroparesis rats, according to the findings. Stimulating these acupoints, on the other hand, can have a different therapeutic effect. In addition, needling local and distal acupoints together can have an antagonistic or synergistic impact on specific physiological and biochemical indexes such as gastric motility, ghrelin, gastrin, and growth factor 1, among others. Our findings demonstrated the benefits of acupoints and acupuncture in the management of diabetic gastroparesis, as well as a new insight into acupuncture therapeutics.

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