期刊
CHINESE JOURNAL OF NATURAL MEDICINES
卷 19, 期 7, 页码 521-527出版社
CHINESE JOURNAL NATURAL MEDICINES
DOI: 10.1016/S1875-5364(21)60051-1
关键词
Hypoxia; Natural product; Human disease; Inhibitor
资金
- Open Project of State Key Laboratory of Natural Medicines [SKLNMKF 202005]
- Macao Science and Technology Development Fund [071/2017/A2]
HIF-1, a key transcriptional regulator of metabolic adaptation to oxygen changes, plays important roles in physiological and pathological processes in the body, and is closely linked to the pathogenesis of many diseases.
Hypoxia-inducible factor 1 (HIF-1), as a main transcriptional regulator of metabolic adaptation to changes in the oxygen environment, participates in many physiological and pathological processes in the body, and is closely related to the pathogenesis of many diseases. This review outlines the mechanisms of HIF-1 activation, its signaling pathways, natural inhibitors, and its roles in diseases. This article can provide new insights in the diagnosis and treatment of human diseases, and recent progress on the development of HIF-1 inhibitors.
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