期刊
IEEE TRANSACTIONS ON MOLECULAR BIOLOGICAL AND MULTI-SCALE COMMUNICATIONS
卷 7, 期 2, 页码 89-93出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMBMC.2021.3083719
关键词
Mathematical model; Apertures; Solid modeling; Shape; Geometry; Biological system modeling; Analytical models; Narrow escape problem; diffusion; signalling; intercellular communication; plasmodesmata; symplastic transport
资金
- EU Horizon 2020 ERC
- Biotechnology and Biological Sciences Research Council (BBSRC) DTP
- BBSRC Institute Strategic Programme Plant Health [BB/P012574/1]
The study evaluates the narrow escape problem as a framework for describing intercellular transport, introducing a volumetric adjustment factor to estimate escape times and providing results for a range of cell sizes and diffusivities. The approach can be extended using recent results on multiple trap problems to account for different plasmodesmata distributions with varying apertures.
Molecular communication is key for multicellular organisms. In plants, the exchange of nutrients and signals between cells is facilitated by tunnels called plasmodesmata. Such transport processes in complex geometries can be simulated using particle-based approaches, these, however, are computationally expensive. Here, we evaluate the narrow escape problem as a framework for describing intercellular transport. We introduce a volumetric adjustment factor for estimating escape times from non-spherical geometries. We validate this approximation against full 3D stochastic simulations and provide results for a range of cell sizes and diffusivities. We discuss how this approach can be extended using recent results on multiple trap problems to account for different plasmodesmata distributions with varying apertures.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据