4.4 Article

Zinc stable isotope analysis reveals Zn dyshomeostasis in benign tumours, breast cancer, and adjacent histologically normal tissue

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Summary: Breast, prostate, and pancreatic cancers alter zinc metabolism, and analysis of urinary zinc concentrations and zinc stable isotope compositions can be used as a non-invasive method to trace malignancy-induced zinc imbalance. Patients with prostate and pancreatic cancer, as well as benign breast disease, show higher urinary zinc concentrations and lower delta Zn-66 compared to healthy controls, while breast cancer patients show undistinguishable zinc stable isotope compositions from the controls.

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