期刊
METALLOMICS
卷 13, 期 6, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/mtomcs/mfab028
关键词
single particle analysis; gold nanoparticles; laser ablation-inductively coupled plasma-mass spectrometry; spleen; particle size distribution
资金
- Bundesministerium fur Bildung und Forschung (BMBF) [03XP0213A, 03XP0213D]
In a dual approach, laser ablation-inductively coupled plasma-mass spectrometry was used to investigate the translocation of polyvinylpyrrolidone-coated gold nanoparticles from the lungs to the spleen in rats. Spatially resolved imaging analysis and single particle analysis were deployed to determine the distribution pattern and species of translocated gold, showing the translocation of intact gold nanoparticles in a non-agglomerated state.
In a dual approach, laser ablation-inductively coupled plasma-mass spectrometry was applied to investigate spleen samples of rats after intratracheal instillation of polyvinylpyrrolidone-coated gold nanoparticles. First, spatially resolved imaging analysis was deployed to investigate gold translocation from the lungs to the spleen and to investigate the distribution pattern of gold in the spleen parenchyma itself. Using the same instrumental setup, laser ablation-inductively coupled plasma-mass spectrometry in single particle mode was applied to determine the species of translocated gold. Single particle analysis allows the determination of particle size distributions and therefore to distinguish between ionic species, intact nanoparticles, and agglomerates. A translocation of instilled gold from the lungs to the spleen was demonstrated for gold nanoparticles of 30 and 50 nm diameter. Furthermore single particle analysis revealed the translocation of intact gold nanoparticles in a non-agglomerated state.
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