期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 36, 期 1, 页码 1553-1563出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756366.2021.1948841
关键词
Antitumour; pyroptosis; HER2 receptor; molecular modelling; benzoxazepines
资金
- Consejeria de Economia, Conocimiento, Empresas y Universidad of the Junta de Andalucia [P18-RT-1679]
- Oficina de Transferencia de Resultados de Investigacion of the University of Granada [PR/17/006]
- Instituto de Salud Carlos III [RTI2018-101309-B-C22]
- Fundacion Mutua Madrilena [FMM-AP16683-2017]
- Consejeria de Salud Junta de Andalucia [PI-0089-2017]
A series of new compounds were synthesized and investigated for their inhibition against HER2 and tumor cell lines, with compounds 9a and 7c showing the most potent activity. Compound 7c increased caspase 1 expression and promoted pyroptosis, indicating a different effect on proteinase expression compared to compound 9a.
A series of 11 new substituted 1,5-dihydro-4,1-benzoxazepine derivatives was synthesised to study the influence of the methyl group in the 1-(benzenesulphonyl) moiety, the replacement of the purine by the benzotriazole bioisosteric analogue, and the introduction of a bulky substituent at position 6 of the purine, on the biological effects. Their inhibition against isolated HER2 was studied and the structure-activity relationships have been confirmed by molecular modelling studies. The most potent compound against isolated HER2 is 9a with an IC50 of 7.31 mu M. We have investigated the effects of the target compounds on cell proliferation. The most active compound (7c) against all the tumour cell lines studied (IC50 0.42-0.86 mu M) does not produce any modification in the expression of pro-caspase 3, but increases the caspase 1 expression, and promotes pyroptosis.
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