Biocompatibility and biodegradability of metal organic frameworks for biomedical applications

Metal organic frameworks (MOFs) are a unique class of smart hybrid materials that have recently attracted significant interest for catalysis, separation and biomedical applications. Different strategies have been developed to overcome the limitations of MOFs for bio-applications in order to produce a system with high biocompatibility and biodegradability. In this review, we outline the chemical and physical factors that dictate the biocompatibility and biodegradability characteristics of MOFs including the nature of the metal ions and organic ligands, size, surface properties and colloidal stability. This review includes the in vitro biodegradation and in vivo biodistribution studies of MOFs to better understand their pharmacokinetics, organ toxicity and immune response. Such studies can guide the design of future bio-friendly systems that bring us closer to safely translating these platforms into the pharmaceutical consumer market.

Automated summary

Metal organic frameworks (MOFs) are smart hybrid materials that have gained significant attention for catalysis, separation, and biomedical applications. Various strategies have been developed to address the limitations of MOFs for bio-applications, aiming to ensure high biocompatibility and biodegradability in the systems.