期刊
EUROPEAN RADIOLOGY
卷 28, 期 1, 页码 428-436出版社
SPRINGER
DOI: 10.1007/s00330-017-4973-y
关键词
Neoplasms; Oesophagus; Prognosis; Positron-emission tomography; Survival
资金
- Tenovus Cancer Care [TIG2016/04]
- Cancer Research Wales [2476]
- EPSRC [EP/M507842/1]
- Velindre NHS Trust [2016/11]
- Cancer Research UK [15954] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [1655771] Funding Source: researchfish
This retrospective cohort study developed a prognostic model incorporating PET texture analysis in patients with oesophageal cancer (OC). Internal validation of the model was performed. Consecutive OC patients (n = 403) were chronologically separated into development (n = 302, September 2010-September 2014, median age = 67.0, males = 227, adenocarcinomas = 237) and validation cohorts (n = 101, September 2014-July 2015, median age = 69.0, males = 78, adenocarcinomas = 79). Texture metrics were obtained using a machine-learning algorithm for automatic PET segmentation. A Cox regression model including age, radiological stage, treatment and 16 texture metrics was developed. Patients were stratified into quartiles according to a prognostic score derived from the model. A p-value < 0.05 was considered statistically significant. Primary outcome was overall survival (OS). Six variables were significantly and independently associated with OS: age [HR =1.02 (95% CI 1.01-1.04), p < 0.001], radiological stage [1.49 (1.20-1.84), p < 0.001], treatment [0.34 (0.24-0.47), p < 0.001], log(TLG) [5.74 (1.44-22.83), p = 0.013], log(Histogram Energy) [0.27 (0.10-0.74), p = 0.011] and Histogram Kurtosis [1.22 (1.04-1.44), p = 0.017]. The prognostic score demonstrated significant differences in OS between quartiles in both the development (X-2 143.14, df 3, p < 0.001) and validation cohorts (X-2 20.621, df 3, p < 0.001). This prognostic model can risk stratify patients and demonstrates the additional benefit of PET texture analysis in OC staging. aEuro cent PET texture analysis adds prognostic value to oesophageal cancer staging. aEuro cent Texture metrics are independently and significantly associated with overall survival. aEuro cent A prognostic model including texture analysis can help risk stratify patients.
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