期刊
EUROPEAN RADIOLOGY
卷 28, 期 5, 页码 2176-2183出版社
SPRINGER
DOI: 10.1007/s00330-017-5209-x
关键词
Myocardial infarction; Optical imaging; Diagnosis; Ultrasonography; Single-photon emission computed tomography
资金
- National Science Foundation of China [81571744, 81601489]
- National Basic Research Program of China (863 Program) [2015AA020502]
- Fundamental Research Funds for the Central Universities [20720170065, 20720170036]
- Science Foundation of Fujian Province [2014Y2004]
This study aimed to demonstrate the capacity for noninvasive localisation and characterisation of myocardial infarction (MI) in vivo using a hemispherical photoacoustic imaging (PAI) system. MI remains a leading cause of morbidity and mortality worldwide. To enable optimal treatment of patients, timely and accurate diagnosis and longitudinal monitoring is critical. Ischaemia was induced in Balb/c mice by ligation of the left anterior descending artery. The hemispherical PAI system, equipped with 128 ultrasonic transducers spirally distributed on the surface, along with parallel data acquisition, was applied for imaging of the mouse heart. Our study showed that hemispherical PAI can delineate thoracic vessels and the morphology of the entire heart. Longitudinal PAI images revealed gradual expansion of the infarcted area along with necrosis and fibrosis, which were quantitatively validated by triphenyltetrazolium chloride staining. After MI modelling, the photoacoustic (PA) signal intensity decreased by 399.1 +/- 56.3 (p < 0.001), a 2.5-fold reduction compared to that of healthy cardiac tissue. The calculated size of the enlarged heart, 10.4 +/- 6.0 mm(2) (p < 0.001), represents an increase of 18% versus that of a healthy heart. PAI enables MI diagnosis and injury localisation with its capabilities for both deep organ imaging and lesion region differentiation. aEuro cent Photoacoustic imaging (PAI), combining optical absorption and ultrasonic resolution, can delineate cardiac anatomy. aEuro cent PAI can diagnose myocardial infarction lesions with 10 mm imaging depth in vivo. aEuro cent Quantified results are in excellent agreement with enzyme and histological examinations. aEuro cent PAI can serve as a complementary modality to SPECT and ultrasound imaging. aEuro cent This study will encourage further PAI development for clinical use.
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