期刊
EUROPEAN RADIOLOGY
卷 28, 期 3, 页码 1140-1148出版社
SPRINGER
DOI: 10.1007/s00330-017-5064-9
关键词
Multiple sclerosis; GABA; H-1-MRS; MEGA-PRESS; Cognitive impairment
资金
- Shandong Provincial Key Research and Development Plan of China [2016ZDJS07A16]
- Shandong Provincial Natural Science Foundation of China [BS2015YY003]
- National Natural Science Foundation of China for Young Scholars [81601479]
- NIH [R01 EB016089, P41 EB015909]
To investigate if brain gamma-aminobutyric acid (GABA) levels in patients with relapsing-remitting multiple sclerosis (RRMS) are abnormal compared with healthy controls, and their relationship to cognitive function in RRMS. Twenty-eight RRMS patients and twenty-six healthy controls underwent magnetic resonance spectroscopy (MRS) at 3-T to detect GABA signals from posterior cingulate cortex (PCC), medial prefrontal cortex (mPFC) and left hippocampus using the 'MEGAPoint Resolved Spectroscopy Sequence' (MEGA-PRESS) technique. All subjects also underwent a cognitive assessment. In RRMS patients, GABA+ were lower in the PCC (p = 0.036) and left hippocampus (p = 0.039) compared with controls, decreased GABA+ in the PCC and left hippocampus were associated with specific cognitive functions (r = -0.452, p = 0.016 and r = 0.451, p = 0.016 respectively); GABA+ in the mPFC were not significantly decreased or related to any cognitive scores (p > 0.05). This study demonstrates that abnormalities of the GABAergic system may be present in the pathogenesis of RRMS and suggests a potential link between regional GABA levels and cognitive impairment in patients with RRMS.
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