期刊
EUROPEAN PSYCHIATRY
卷 44, 期 -, 页码 125-133出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.eurpsy.2017.04.004
关键词
Schizophrenia; Motor Dysfunction; Motor Cortex; Dopamine
类别
资金
- Career Development Chair from Wayne State University
- Charles H. Gershenson Distinguished Faculty Fellowship from Wayne State University
- Lyckaki-Young Fund from the State of Michigan
- Prechter Family Bipolar Foundation
- Children's Hospital of Michigan Foundation
- Children's Research Center of Michigan
- Cohen Neuroscience Endowment
- National Institute of Mental Health [MH 59299, MH111177]
Motor control is a ubiquitous aspect of human function, and from its earliest origins, abnormal motor control has been proposed as being central to schizophrenia. The neurobiological architecture of the motor system is well understood in primates and involves cortical and sub-cortical components including the primary motor cortex, supplementary motor area, dorsal anterior cingulate cortex, the prefrontal cortex, the basal ganglia, and cerebellum. Notably all of these regions are associated in some manner to the pathophysiology of schizophrenia. At the molecular scale, both dopamine and gAminobutyric Acid (GABA) abnormalities have been associated with working memory dysfunction, but particularly relating to the basal ganglia and the prefrontal cortex respectively. As evidence from multiple scales (behavioral, regional and molecular) converges, here we provide a synthesis of the biobehavioral relevance of motor dysfunction in schizophrenia, and its consistency across scales. We believe that the selective compendium we provide can supplement calls arguing for renewed interest in studying the motor system in schizophrenia. We believe that in addition to being a highly relevant target for the study of schizophrenia related pathways in the brain, such focus provides tractable behavioral probes for in vivo imaging studies in the illness. Our assessment is that the motor system is a highly valuable research domain for the study of schizophrenia. (C) 2017 Elsevier Masson SAS. All rights reserved.
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