4.7 Article

Transcription factor specificity protein 1-mediated Serine/threonine kinase 39 upregulation promotes the proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells by activating the transforming growth factor-β1/Smad2/3 pathway

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STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway

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Summary: The study revealed that STK39 is highly overexpressed in clinical HCC tissues, induced by transcription factor SP1, and correlated with poor patient survival. Overexpression of STK39 promoted HCC cell proliferation, migration, and invasion, while depletion of STK39 attenuated growth and metastasis. Knockdown of STK39 induced HCC cell cycle arrest and apoptosis.

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