期刊
INFLAMMATION AND REGENERATION
卷 41, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s41232-021-00174-7
关键词
Gastrointestinal fibrosis; Crohn's disease; Endoscopic surgery
资金
- Japan Society for the Promotion of Science (JSPS) KAKENHI [20H03666, 20H00536]
- Advanced Research and Development Programs for Medical Innovation (AMED-CREST) [16gm1010003h0001, 20gm1210001h0002, 21ek0109556h0001]
- Takeda Science Foundation
- Kanae Foundation for The Promotion of Medical Science
- Mishima Kaiun Memorial Foundation Research Grant
- Yakult Bio-Science Foundation
- Keio University Medical Fund
- Grants-in-Aid for Scientific Research [20H00536, 20H03666] Funding Source: KAKEN
Gastrointestinal fibrosis is a condition of accumulated biological entropy caused by dysregulated tissue repair response, often seen in cases of acute or chronic inflammation in the gastrointestinal tract, particularly in patients with Crohn's disease. Current understanding of the pathogenesis of gastrointestinal fibrosis is limited, highlighting the need for further development of prevention and treatment strategies.
Gastrointestinal fibrosis is a state of accumulated biological entropy caused by a dysregulated tissue repair response. Acute or chronic inflammation in the gastrointestinal tract, including inflammatory bowel disease, particularly Crohn's disease, induces fibrosis and strictures, which often require surgical or endoscopic intervention. Recent technical advances in endoscopic surgical techniques raise the possibility of gastrointestinal stricture after an extended resection. Compared to recent progress in controlling inflammation, our understanding of the pathogenesis of gastrointestinal fibrosis is limited, which requires the development of prevention and treatment strategies. Here, we focus on gastrointestinal fibrosis in Crohn's disease and post-endoscopic submucosal dissection (ESD) stricture, and we review the relevant literature.
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