4.7 Article

A Mn-catalyzed remote C(sp3)-H bond peroxidation triggered by radical trifluoromethylation of unactivated alkenes

期刊

CHEMICAL COMMUNICATIONS
卷 57, 期 63, 页码 7846-7849

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc03295j

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资金

  1. National Natural Science Foundation of China [22071266]
  2. Fundamental Research Funds for the Central Universities
  3. Research Funds of Renmin University of China [21XNLG04]

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This study presents a manganese-catalyzed radical relay strategy for the remote trifluoromethylation-peroxidation of unactivated alkenes, delivering 1,6-difunctionalized products selectively under mild conditions. The electrophilic CF3 group is added to double bonds, generating remote C-centered radicals upon 1,5-HAT, which are efficiently trapped by Mn(n+)1OOBu-t species. t-BuOOH serves as both the oxidant and peroxy precursor in this transformation.
A manganese-catalyzed radical relay strategy for the remote trifluoromethylation-peroxidation of unactivated alkenes is disclosed. The electrophilic CF3 group was added to the C=C double bonds to afford remote C-centered radicals upon 1,5-HAT, which could be efficiently trapped by Mn(n+)1OOBu-t species to deliver 1,6-difunctionalized products selectively under mild conditions. t-BuOOH serves as both the oxidant and the peroxy precursor in this transformation.

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