4.7 Review

Immune-based therapies in cardiovascular and metabolic diseases: past, present and future

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Apoptotic Ablation of Platelets Reduces Atherosclerosis in Mice With Diabetes

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Summary: Reducing platelet numbers through targeting the antiapoptotic protein Bcl-x(L) can effectively decrease atherosclerosis and reduce cardiovascular disease risk in diabetes, as demonstrated in genetic and pharmacological approaches in this study.

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Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis

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Summary: This study found that inhibiting the NLRP3 inflammasome with MCC950 could reduce inflammation, improve vascular function, and protect against diabetes-associated atherosclerosis. The results suggest that targeting NLRP3-mediated inflammation could be a novel therapeutic strategy to improve diabetes-related vascular disease.

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Alarmin-activated B cells accelerate murine atherosclerosis after myocardial infarction via plasma cell-immunoglobulin-dependent mechanisms

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EUROPEAN HEART JOURNAL (2021)

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The Role of Colchicine in Atherosclerotic Cardiovascular Disease

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Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease

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Adelie Dumont et al.

Summary: This review discusses the roles of macrophage mitochondrial metabolic diversity in atherosclerosis and their potential as biomarkers. Mitochondria not only play a key role in metabolism but also serve as a signaling platform, integrating various regulations that affect macrophage functions in atherosclerosis. Understanding how these processes are integrated and influence macrophage functions may lead to the development of novel therapeutic approaches.

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In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates

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Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis

Michelle C. Flynn et al.

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Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque

Zsofia D. Drobni et al.

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Colchicine in Patients with Chronic Coronary Disease

Stefan M. Nidorf et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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CXCR4 antagonist AMD3100 (plerixafor): From an impurity to a therapeutic agent

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By Releasing the Brakes With Immunotherapy, Are We Accelerating Atherosclerosis?

Lavanya Kondapalli et al.

CIRCULATION (2020)

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NETosis Is Required for S100A8/A9-Induced Granulopoiesis After Myocardial Infarction

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Jelena Todoric et al.

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CXCL12 Derived From Endothelial Cells Promotes Atherosclerosis to Drive Coronary Artery Disease

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Identification of preexisting adaptive immunity to Cas9 proteins in humans

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Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

Jean-Claude Tardif et al.

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The haematopoietic stem cell niche: a new player in cardiovascular disease?

Annas Al-Sharea et al.

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Immunity and Inflammation in Atherosclerosis

Dennis Wolf et al.

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Low-Dose Methotrexate for the Prevention of Atherosclerotic Events

Paul M. Ridker et al.

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GIP regulates inflammation and body weight by restraining myeloid-cell-derived S100A8/A9

Fernanda Dana Mantelmacher et al.

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Grant R. Drummond et al.

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Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis, and Atherogenesis

Marit Westerterp et al.

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Residual Inflammatory Risk on Treatment With PCSK9 Inhibition and Statin Therapy

Aruna D. Pradhan et al.

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Defective cholesterol metabolismin haematopoietic stem cells promotes monocyte-driven atherosclerosis in rheumatoid arthritis

Dragana Dragoljevic et al.

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Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

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Wei-Hsi Yeh et al.

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Evidence against a role for NLRP3-driven islet inflammation in db/db mice

H. L. Kammoun et al.

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Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis

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Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes

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NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report

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Boosting Inflammation Resolution in Atherosclerosis The Next Frontier for Therapy

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Pleiotropic Effects of Statins on the Cardiovascular System

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Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

Thekla Cordes et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Alexis C. Komor et al.

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Maraviroc Reduces Arterial Stiffness in PI-Treated HIV-infected Patients

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Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease

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Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice

S. M. van den Berg et al.

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IL-17 and Th17 Cells in Atherosclerosis Subtle and Contextual Roles

Soraya Taleb et al.

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Deficiency of ATP-Binding Cassette Transporter B6 in Megakaryocyte Progenitors Accelerates Atherosclerosis in Mice

Andrew J. Murphy et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

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HDL in innate and adaptive immunity

Alberico Luigi Catapano et al.

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Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

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miR33 Inhibition Overcomes Deleterious Effects of Diabetes Mellitus on Atherosclerosis Plaque Regression in Mice

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Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

Stanley Ching-Cheng Huang et al.

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Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

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CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE/ mice

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Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis

Prabhakara R. Nagareddy et al.

CELL METABOLISM (2013)

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Targeting gp130 to prevent inflammation and promote insulin action

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Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

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Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

G. M. Tannahill et al.

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Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis

Andrew J. Murphy et al.

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Leukocyte Behavior in Atherosclerosis, Myocardial Infarction, and Heart Failure

Filip K. Swirski et al.

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Transsignaling of Interleukin-6 Crucially Contributes to Atherosclerosis in Mice

Harald Schuett et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

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Interleukin-17A Deficiency Accelerates Unstable Atherosclerotic Plaque Formation in Apolipoprotein E-Deficient Mice

Keiko Danzaki et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

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Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat

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JOURNAL OF IMMUNOLOGY (2012)

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Myocardial infarction accelerates atherosclerosis

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NATURE (2012)

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Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

Katey J. Rayner et al.

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Article Medicine, Research & Experimental

ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

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JOURNAL OF CLINICAL INVESTIGATION (2011)

Review Medicine, General & Internal

MECHANISMS OF DISEASE The Pathogenesis of Rheumatoid Arthritis

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NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Blockade of Interleukin-17A Results in Reduced Atherosclerosis in Apolipoprotein E-Deficient Mice

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CIRCULATION (2010)

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ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

Laurent Yvan-Charvet et al.

SCIENCE (2010)

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MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

Katey J. Rayner et al.

SCIENCE (2010)

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Charles A. Dinarello

ANNUAL REVIEW OF IMMUNOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Acute coronary syndrome associated with essential thrombocythemia

Naoko Kumagai et al.

JOURNAL OF CARDIOLOGY (2009)

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Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

Rory R. Koenen et al.

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High-Density Lipoprotein Reduces the Human Monocyte Inflammatory Response

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Infusion of Reconstituted High-Density Lipoprotein Leads to Acute Changes in Human Atherosclerotic Plaque

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Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis -: A randomized controlled trial

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Programmed anuclear cell death delimits platelet life span

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Filip K. Swirski et al.

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Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

Frank Tacke et al.

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LE Bernstein et al.

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Relationship between atheroma regression and change in lumen size after infusion of apolipoprotein A-I Milano

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CCR2 modulates inflammatory and metabolic effects of high-fat feeding

SP Weisberg et al.

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HDL as a target in the treatment of atherosclerotic cardiovascular disease

P Linsel-Nitschke et al.

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Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease

SE Nissen et al.

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Inhibition of tumor necrosis factor-α reduces atherosclerosis in apolipoprotein E knockout mice

L Branén et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)

Article Medicine, General & Internal

Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes - A randomized controlled trial

SE Nissen et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)

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Tumor necrosis factor-alpha and myocardial remodeling in progression of heart failure: a current perspective

WS Bradham et al.

CARDIOVASCULAR RESEARCH (2002)

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Reactive oxygen species in mechanical stress-induced cardiac hypertrophy

R Aikawa et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

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Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice

A Daugherty et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)